Wednesday June 20, 2007
Resistant (uncontrolled bleeding) / Life-threatening diffuse alveolar
hemorrhageDiffuse alveolar hemorrhage remained a condition with high mortality. Usual treatment is high dose IV metilprednisolone (1g/day) for three to five days and in more severe cases to add IV cyclophosphamide (cyclophosphamide has a delayed effect, but may provide synergistic action with steroid). Plasmapheresis has been described to be effective particularly in diffuse alveolar hemorrhage associated with Goodpasture syndrome.But what if bleeding is non-stop and life-threatening ?Answer is off label use of activated Factor VII. In 3 cases reported from University of North Carolina at Chapel Hill - bleeding stops and oxygenation improved within minutes 1.
Reference: click to get abstract
Successful Treatment of Diffuse Alveolar Hemorrhage with Activated Factor VII - 16 March 2004 Volume 140 Issue 6 Pages 493-494
6 comments:
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